Diazepam – An Introduction
Diazepam is one widely prescribed drug which has now been included in the Essential Drug List of World Health Organization. The WHO Essential Drug list consists of the drugs which are highly important life-saving drugs. This alone explains the significance of Diazepam in health care systems. Diazepam is extensively recommended for a wide variety of medical conditions. Diazepam is one of the most frequently prescribed drug in the pharmaceutical history.
Diazepam – When to Use it?
If you have developed anxiety disorder, there is a high probability that your doctor would prescribe you Diazepam. Diazepam is derivative of Benzodiazepine and it works on the neurochemicals. Our brain releases certain chemicals which are responsible for our mood changes and emotions. Certain circumstances disturb the balance of these chemical levels hence dragging you into a state of anxiety, restlessness, insomnia, and agitation. Severe anxiety disorders lead to hallucinations, shake ups, and seizures. In such a health condition Diazepam is prescribed for relief. Diazepam is also prescribed to the patients who have withdrawn from drugs or alcohol.
Diazepam- Active Ingredient
The active ingredient in Diazepam is Benzodiazepine. Benzodiazepine is a neuro-active ingredient and works on the brain’s chemical levels.
Diazepam- Mechanism of Action
As sated earlier, Diazepam is a psychoactive drug and it works on the neurochemicals. The main function of the drug is to re-establish the balance in the chemical level.
To understand the mechanism of Diazepam’s action, we need to understand the brain’s
functionality. One of the main functions of the human brain is to adapt the body to the
environment. Brian performs this function by responding to body receptors which gives
information to the brain about the environment. GABA is one of these receptors which
releases certain chemicals and controls the excitability of the brain. These chemical levels, when balanced, keep the excitability of the brain to normal level. Any positive or negative change in their balances disturbs the way our brain works and hence the body experience anxiety disorders. Diazepam brings the excitability of brain neurons to normal level by working on GABA. GABA has subunits and inhibitory channels. GABAA receptor is one of these inhibitory channels, which is activated to slow down the neuronal action. Diazepam works on the Cerebral cortex and performs action on the limbic system, the body parts controlled by thalamus and hypothalamus. Diazepam also relaxes the muscles by inhibiting the polysynaptic trails in the spinal cord. Benzodiazepine containing diazepam does not affect the GABA levels but inhibits the neuron activity by controlling the negative chloride ions. The mechanism of Diazepam’s action is thus classified as inhibitory.
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